Mutations in OTCase

The following model of OTCase is displayed using an open-source java application, Jmol, that allows interactive visualization of protein structures. It may take a little time to load. You can use the mouse to click and drag to rotate the molecule. If you are familiar with Rasmol/Chime commands, you can right-mouse click (Control-click on Mac) on the image to bring up a console menu. If you have a scroll wheel on your mouse, you can zoom in and out

Click on a molecule to display the monomer or trimer

(Backbone model is a good view to use for visualizing mutations)

Clicking on Active site will show where PALO binds.

Fancy dissolve and spin

Click to show the locations of missense mutations.
Late onset

Adjust the size of spheres